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KMID : 0380020150300050239
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Korean Journal of Biotechnology and Bioengineering
2015 Volume.30 No. 5 p.239 ~ p.244
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Characterization and Antimicrobial Activity against Gardnerella vaginalis of Vaginal Lactobacillus spp. Isolated from Korean Women
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Kim Yong-Gyeong
Kang Chang-Ho
Shin Yu-Jin
Paek Nam-Soo
So Jae-Seong
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Abstract
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Bacterial vaginosis (BV) is caused by microbial imbalance of the vaginal ecosystem and overgrowth of anaerobic bacteria. The antibiotic treatment often results in very high recurrence of BV because it disturbs the vaginal ecosystem. The high recurrence rates suggest a need for alternative therapeutic methods and probiotics are being recognized as alternative or additional treatment method for BV. The purpose of this study was to investigate how human vaginal isolates of Lactobacillus spp. inhibit the BV-associated pathogen Gardnerella vaginalis. Results show that selected strains significantly reduced the viability of G. vaginalis. Among these selected strains KLB410 and KLB416 were further selected based on acid/bile tolerance and identified through 16S rRNA gene sequencing being Lactobacillus plantarum. Further studies are underway to demonstrate that the selected strain can be applied as potential probiotics for recovering vaginal ecosystem.
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KEYWORD
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Bacterial vaginosis, Gardnerella vaginalis, Probiotics, Lactobacillus spp.
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